Here Are the Best Shows We’ll Binge on Amazon Prime in September 2025

September is packed with new originals and big returning series on Prime Video, along with a few cult favorites arriving for the first time. Whether you want glossy thrillers, campus super hero chaos, fresh K drama capers, or music driven coming of age stories, there is a lot to line up on your watchlist.

Below you will find the ten standouts that hit Prime Video throughout the month. Each pick includes what the show is about along with key cast and creative details so you can jump in knowing who made it and why its story might grab you.

‘The Girlfriend’ (2025)

This psychological thriller follows Laura, a high powered mother whose life tilts when her adult son brings home a new partner and red flags begin to pile up. The series adapts Michelle Frances’ bestselling novel and unfolds across six episodes that trace a tightening spiral between a wary parent and the woman she believes may be targeting her family.

Robin Wright stars as Laura and also directs, with Olivia Cooke as Cherry and Laurie Davidson as Danny. The ensemble includes Waleed Zuaiter, Anna Chancellor, Francesca Corney, Shalom Brune Franklin, Leo Suter, Tanya Moodie, and more, with Imaginarium Productions and Amazon MGM Studios producing.

‘Gen V’ (2023–)

Set in the world of ‘The Boys’, this series returns to Godolkin University where young supes train for glory while uncovering secrets that reach back to the school’s founding. The new chapter arrives with a three episode premiere on September 17 followed by weekly releases and continues storylines that connect directly to the flagship series.

Jaz Sinclair, Lizze Broadway, Maddie Phillips, London Thor, Derek Luh, Asa Germann, and Maia Jae Bastidas lead the ensemble, with Hamish Linklater joining as the new dean. The show is developed by Eric Kripke, Seth Rogen, and Evan Goldberg, with Michelle Fazekas as showrunner, and features recurring appearances from familiar faces in ‘The Boys’ universe.

‘The Runarounds’ (2025)

A tight knit group of recent high school grads forms a band and chases a first big break in Wilmington, North Carolina. The story blends rehearsal room tensions with friendships and first loves while weaving in original music performed by the cast.

Created by Jonas Pate of ‘Outer Banks’, the series stars real life musicians William Lipton, Axel Ellis, Jeremy Yun, Zendé Murdock, and Jesse Golliher. Supporting players include Brooklyn Decker, Hayes MacArthur, Maximo Salas, Kelley Pereira, Shea Pritchard, and Mark Wystrach, with Prime Video releasing all eight episodes.

‘Hotel Costiera’ (2025)

This Italian English language action drama follows Daniel DD De Luca, a former Marine who takes a fixer job at a luxury hotel on the Amalfi Coast. When the owner’s daughter goes missing, his discrete problem solving expands into a dangerous search that winds through coastal glamour and criminal networks.

Jesse Williams headlines as DD alongside Maria Chiara Giannetta, Jordan Alexandra, Antonio Gerardi, Sam Haygarth, Tommaso Ragno, Amanda Campana, Pierpaolo Spollon, Alejandra Onieva, and Jean Hugues Anglade. The series is created by Elena Bucaccio, Matthew Parkhill, and Francesco Arlanch, directed by Adam Bernstein and Giacomo Martelli, and produced by Amazon Studios and Lux Vide.

‘Confidence Queen’ (2025)

A stylish caper from South Korea centers on Yi rang, a brilliant swindler who assembles a small team to target corrupt power players through elaborate stings. Each case balances charm and sleight of hand with a code that reserves their tricks for villains who profit from others.

Park Min young leads as Yi rang with Joo Jong hyuk as Myung Gu ho and Park Hee soon as James. The series is directed by Nam Ki hoon and written by Hong Seung hyun with Kim Da hye, and it is a remake inspired by the hit Japanese format that reimagines the cons inside modern real estate and finance arenas.

‘Dish It Out’ (2025)

Tilly Ramsay hosts this upbeat cooking series that mixes viral food trends with family favorites and surprise challenges. Episodes feature mystery ingredient boxes, recipes sent in by chefs and creators, and plenty of kitchen guests who jump in to cook alongside the host.

Matilda Tilly Ramsay leads the show with appearances from Gordon Ramsay, Tana Ramsay, and a wide range of celebrity and culinary influencers across a 32 episode first season. The series is produced by Tastemade Studios in partnership with Amazon MGM Studios, with the first drop arriving on September 5 and additional episodes rolling out weekly.

‘Top End Bub’ (2025)

A follow up to the film ‘Top End Wedding’, this eight part series finds Indigenous lawyer Lauren and her baker husband Ned becoming guardians to their lively niece after a family tragedy. They leave city life for the Northern Territory and juggle new parenthood with culture, community, and career.

Miranda Tapsell and Gwilym Lee reprise their roles as Lauren and Ned from the film, with the series created and written by Tapsell and Joshua Tyler and produced by Goalpost Pictures. Direction is by Christiaan Van Vuuren and Shari Sebbens, with the story set across Adelaide, Darwin, and the Top End.

‘Every Minute Counts’ (2024–)

This ensemble drama reconstructs the critical hours during and after the 1985 Mexico City earthquake. Interlocking storylines follow a doctor and nurses inside a collapsing hospital, a reporter crisscrossing the city, and families searching for loved ones as the day unfolds minute by minute.

Created by filmmaker Jorge Michel Grau, the show features Jesús Zavala, Osvaldo Benavides, Maya Zapata, Antonio de la Vega, Everardo Arzate, and Damayanti Quintanar. Season one premiered in 2024, and new episodes arrive in September that continue the rescue timeline while exploring official responses and the mounting aftershock threat.

‘Helluva Boss’ (2020–)

Set in the same universe as ‘Hazbin Hotel’, this adult animated series follows the Immediate Murder Professionals, a demon run startup that takes assassination gigs in the human world. Episodes mix workplace chaos with musical numbers and a messy constellation of relationships in and around Hell.

Creator Vivienne Medrano leads SpindleHorse’s production with voice talent that includes Brandon Rogers as Blitzo, Richard Steven Horvitz as Moxxie, Vivian Nixon as Millie, and Erica Lindbeck as Loona. Seasons one and two land on Prime Video with the uncensored cuts and a growing slate of songs and shorts tied to the series.

‘American Horror Story’ (2011–)

Ryan Murphy and Brad Falchuk’s anthology moves through different horror settings each season while keeping a repertory company of stars across its run. Stories have ranged from haunted mansions to covens and circuses, with each chapter standing alone and connecting through recurring motifs and characters.

The franchise has featured Jessica Lange, Sarah Paulson, Evan Peters, Angela Bassett, Kathy Bates, Emma Roberts, and many others, with Twentieth Television producing. The latest season arrives on Prime Video for streaming, adding to a long running catalog that continues to experiment with tone, structure, and theme.

Tell us which of these you are starting first and what else you are queuing up on Prime this month in the comments.