Amy Schumer Opens Up About Her Weight-Loss Medications and Health Struggles in Candid Confession
Amy Schumer is entering 2026 with a commitment to radical transparency, particularly regarding her health and the pharmaceutical assistance she utilized during her recent weight-loss journey.
While many Hollywood stars remain tight-lipped about their methods, the 44-year-old comedian has made it her mission to “be real with the people.” In a series of candid updates, Schumer revealed that her path to feeling “pain-free” involved navigating a complex web of hormonal treatments, weight-loss drugs, and a significant medical diagnosis.
The journey hasn’t been without its setbacks, specifically regarding GLP-1 medications like Wegovy and Ozempic. I was puking. I couldn’t handle it, Schumer shared of her experience with Wegovy. She noted that the side effects were so severe they interfered with her ability to parent. I was one of those people that felt so sick and couldn’t play with my son, she explained during an appearance on Watch What Happens Live. Despite losing 30 pounds quickly, she found the extreme nausea “not livable,” leading her to stop the treatment.
Schumer later discovered a genetic reason for her struggle: the GDF15 gene, which makes her highly prone to nausea. This was the same factor that caused her severe illness during pregnancy, and it made the side effects of Ozempic feel like being bedridden. I looked great, but I couldn’t lift my head off the pillow. So what’s the point? she remarked. Eventually, she found a better fit with Mounjaro, which she credits for helping her manage her weight without the debilitating sickness.
Beyond weight management, Schumer’s health journey took a serious turn in early 2024 when she was diagnosed with Cushing syndrome. The condition, caused by an excess of cortisol, led to the “puffy face” that many internet commenters had criticized. I had a disease that makes your face extremely puffy that can kill you but the internet caught it and that disease has been cleared, she stated in a December 2025 update. Today, she manages her health through Mounjaro alongside estrogen and progesterone for pre-menopause symptoms.
Professionally, Schumer is celebrating a massive career resurgence following the release of her Netflix comedy Kinda Pregnant in February 2025. The film, which she both wrote and starred in, became one of the streamer’s biggest hits of the year, amassing over 25 million views in its first week. Starring alongside Jillian Bell and Will Forte, Schumer played a woman who fakes a pregnancy to gain social status, a role she described as her “return to movies.”
Her 2026 calendar is focused on “self-care and self-love,” but she isn’t stepping away from the spotlight entirely. While her Hulu series Life & Beth concluded after two seasons, she remains in active development on a long-rumored mother-daughter comedy produced by Paul Feig.
By speaking openly about everything from liposuction to hormone replacement therapy, Schumer aims to dismantle the “smaller portions” narrative often used by celebrities. Like shut the f **** up. You are on Ozempic or one of those things or you got work done. Just stop, she urged her peers. For Schumer, the goal of 2026 is simple: staying healthy enough to play tag with her son and remaining unbothered by the internet’s expectations.
What do you think about Amy Schumer’s decision to call out other celebrities for being dishonest about their weight-loss methods? Share your thoughts in the comments.