Actresses Who Overcame Serious Illnesses

Our Editorial Policy.

Share:

Many prominent figures in Hollywood have faced significant health challenges throughout their successful careers. These actresses have used their platforms to share stories of survival and resilience after receiving life altering diagnoses. From chronic autoimmune diseases to aggressive forms of cancer, these women have navigated the complexities of treatment while remaining in the public eye. Their experiences often serve as inspiration for fans and help raise awareness for various medical conditions.

Selena Gomez

Selena Gomez
TMDb

The performer has been open about her battle with lupus for many years. She underwent a kidney transplant in 2017 due to complications from the autoimmune disease. Her recovery included significant time away from the spotlight to focus on her personal health. She starred in ‘Only Murders in the Building’ while continuing to advocate for wellness awareness. The actress remains a prominent figure in the global conversation regarding chronic illness management.

Christina Applegate

Christina Applegate
TMDb

This actress faced a breast cancer diagnosis in 2008 and chose to undergo a double mastectomy. Years later she revealed a diagnosis of multiple sclerosis while filming the final season of ‘Dead to Me’. She has been vocal about the physical toll the disease takes on her body and career. Her transparency has helped many people understand the realities of living with a degenerative condition. She continues to appear at events to support research and fellow patients.

Julia Louis-Dreyfus

Julia Louis-Dreyfus
TMDb

In 2017 the celebrated star of ‘Veep’ announced that she was undergoing treatment for breast cancer. She completed several rounds of chemotherapy before returning to finish the final season of her hit comedy series. Her recovery journey was shared with fans through social media updates that blended humor with honesty. She has since become an advocate for affordable healthcare and cancer research. The actress successfully completed her treatment and continues to work on high profile film projects.

Sharon Stone

Sharon Stone
TMDb

The ‘Basic Instinct’ star suffered a massive brain hemorrhage and stroke in 2001. She spent several years relearning how to walk and talk during a long recovery process. The medical emergency nearly ended her career and significantly impacted her personal life for nearly a decade. She eventually returned to the screen in projects like ‘Ratched’ and became a spokesperson for brain health. Her story highlights the importance of recognizing the symptoms of a stroke.

Emilia Clarke

Emilia Clarke
TMDb

Known for her role in ‘Game of Thrones’ this actress survived two life threatening brain aneurysms. The first occurred shortly after she finished filming the first season of the popular fantasy series. She underwent multiple surgeries to address the subarachnoid hemorrhages while continuing her demanding work schedule. She eventually founded a charity called SameYou to help young people recover from brain injuries. Her resilience allowed her to complete all eight seasons of her record breaking show.

Sarah Hyland

Sarah Hyland
TMDb

The ‘Modern Family’ actress was born with kidney dysplasia and has undergone two kidney transplants. Her first transplant was donated by her father and the second was provided by her brother. She has endured dozens of surgeries and chronic pain throughout her time on the popular sitcom. Despite these health hurdles she maintained a successful career and often shares photos of her surgical scars. She continues to speak out about the importance of organ donation.

Cobie Smulders

Cobie Smulders
TMDb

While filming ‘How I Met Your Mother’ this actress was diagnosed with ovarian cancer at the age of 25. She underwent multiple surgeries over two years to remove the cancerous tissue. She kept her health battle private for several years before sharing her story to help other women. She successfully went on to have children despite initial fears regarding her fertility. The actress later joined the Marvel Cinematic Universe as the character Maria Hill.

Kathy Bates

Kathy Bates
TMDb

This Academy Award winner survived both ovarian cancer and breast cancer over the course of her career. Following a double mastectomy she developed lymphedema which causes chronic swelling in the limbs. She has become a national spokesperson for lymphedema awareness to help others manage the condition. Despite these challenges she has continued to star in major productions like ‘American Horror Story’. Her career has remained prolific as she advocates for better medical research and patient support.

Rita Wilson

Rita Wilson
TMDb

The actress and singer was diagnosed with invasive lobular carcinoma in 2015. She underwent a double mastectomy and reconstructive surgery to treat the breast cancer. She credits a second medical opinion for helping her catch the illness in its early stages. Since her recovery she has appeared in films like ‘Kimi’ and released several albums. She often encourages women to seek multiple professional opinions when facing serious health concerns.

Fran Drescher

Fran Drescher
TMDb

The star of ‘The Nanny’ battled uterine cancer and spent two years seeking a correct diagnosis. She eventually underwent a radical hysterectomy to ensure the cancer was fully removed. Following her recovery she founded the Cancer Schmancer Movement to focus on early detection. She has written books about her experience and remains a vocal advocate for women’s health. Her work in the industry continues as she leads major organizations and stars in new projects.

Sofía Vergara

Sofía Vergara
TMDb

At the age of 28 the ‘Modern Family’ star was diagnosed with thyroid cancer. She underwent surgery to remove her thyroid gland and followed the procedure with iodine radiation therapy. She has managed her health through daily medication ever since the successful treatment. The actress has been a longtime supporter of cancer charities and research initiatives. Her career reached new heights after her recovery as she became one of the highest paid actresses on television.

Jane Fonda

Jane Fonda
TMDb

This Hollywood icon has survived several bouts of cancer including skin cancer and breast cancer. In 2022 she announced she was undergoing treatment for Non Hodgkin Lymphoma. She remained active in her activism and professional work throughout her chemotherapy sessions. She eventually shared that her cancer was in remission and she felt stronger than ever. Her long career in films like ‘Grace and Frankie’ serves as a testament to her enduring strength.

Cynthia Nixon

Cynthia Nixon
TMDb

The ‘Sex and the City’ star was diagnosed with breast cancer during a routine mammogram in 2006. She initially kept her diagnosis private while undergoing lumpectomy and radiation treatments. She later became an official spokesperson for a major breast cancer foundation to help raise awareness. Her activism extends into the political sphere where she advocates for improved healthcare access. She has continued her acting career with roles in ‘The Gilded Age’ and other major series.

Maura Tierney

Maura Tierney
TMDb

Known for her work on ‘ER’ the actress had to leave a television project after being diagnosed with breast cancer. She underwent surgery and chemotherapy which resulted in a significant break from her acting duties. She returned to the screen in the acclaimed series ‘The Affair’ for which she won a Golden Globe. Her recovery allowed her to resume a high level of performance in both television and theater. She has spoken about how the experience changed her perspective on life and work.

Edie Falco

Edie Falco
TMDb

The star of ‘The Sopranos’ was diagnosed with breast cancer in 2003 while the show was still in production. She chose to keep the news quiet and worked through her treatment without missing any filming dates. She credited her sobriety and healthy lifestyle for helping her navigate the physical demands of recovery. After being declared cancer free she went on to star in the lead role of ‘Nurse Jackie’. Her ability to maintain her professional commitments during such a difficult time remains impressive.

Wanda Sykes

Wanda Sykes
TMDb

The comedian and actress discovered she had ductal carcinoma in situ during a breast reduction surgery. She opted for a bilateral mastectomy to eliminate the risk of the cancer returning or spreading. She has since used her stand up specials to talk about her health journey with her signature humor. Her career continues to flourish with voice work and roles in shows like ‘The Upshaws’. She remains a strong advocate for regular health screenings and preventative care.

Catherine Zeta-Jones

Catherine Zeta-Jones
TMDb

The Oscar winning actress revealed in 2011 that she had been diagnosed with Bipolar Two disorder. She sought professional treatment at a mental health facility to manage the symptoms of the condition. Her openness helped reduce the stigma surrounding mental health issues in the entertainment industry. She has continued to work on major projects including the hit series ‘Wednesday’. Her story highlights the importance of seeking help for mental health just as one would for physical illness.

Maria Menounos

Maria Menounos
TMDb

This actress and television host was diagnosed with a benign brain tumor in 2017. She underwent a complex surgery to remove the mass while her mother was also battling stage four brain cancer. In 2023 she faced another major health challenge when she was diagnosed with stage two pancreatic cancer. She underwent successful surgery to remove the tumor and has since become an advocate for early detection. Her resilience through multiple health crises has inspired many of her viewers.

Sheryl Crow

Sheryl Crow
TMDb

The singer and actress was diagnosed with ductal carcinoma in situ in 2006. She underwent a lumpectomy and several weeks of radiation therapy to treat the breast cancer. A few years later she was also diagnosed with a benign brain tumor known as a meningioma. She has maintained a healthy lifestyle and continues to perform and act in various projects. She is a frequent supporter of cancer research and emphasizes the role of environmental factors in health.

Maggie Smith

Maggie Smith
TMDb

While filming ‘Harry Potter and the Half-Blood Prince’ the legendary actress was undergoing treatment for breast cancer. She insisted on finishing her work on the film despite the grueling side effects of chemotherapy. Her dedication to her craft during her recovery earned her even more respect from her colleagues and fans. She successfully beat the disease and continued to star in ‘Downton Abbey’ for many years. Her career remains one of the most celebrated in the history of British cinema.

Jamie-Lynn Sigler

Jamie-Lynn Sigler
TMDb

The actress known for ‘The Sopranos’ was diagnosed with multiple sclerosis when she was only 20 years old. She kept her condition a secret for fifteen years before publicly sharing her journey in 2016. She has spoken candidly about how the disease affects her mobility and her work on set. Despite the challenges of the condition she has continued to act in shows like ‘Big Sky’. She is now a leading voice in the community of people living with chronic illness.

Lena Dunham

Lena Dunham
TMDb

The creator and star of ‘Girls’ has been very public about her long battle with endometriosis. After years of chronic pain and numerous surgeries she made the decision to undergo a total hysterectomy. She has written extensively about the physical and emotional impact of the disease and the surgery. Her transparency has helped bring national attention to a condition that affects many women. She remains active in the industry as a writer and director.

Tia Mowry

Tia Mowry
TMDb

The ‘Sister, Sister’ star was diagnosed with endometriosis after years of suffering from undiagnosed pain. She changed her diet and lifestyle to help manage the symptoms of the condition and improve her fertility. Her efforts were successful and she has since become a mother of two children. She has written books about her health journey and the importance of self advocacy in medical settings. She continues to star in various television movies and reality programs.

Kate Walsh

Kate Walsh
TMDb

The ‘Grey’s Anatomy’ star was diagnosed with a large brain tumor in 2015. She underwent surgery to remove the benign mass just days after the initial discovery. She took a significant break from acting to focus on her recovery and brain health. She eventually returned to the screen in the hit series ’13 Reasons Why’ and ‘Emily in Paris’. Her experience led her to advocate for regular health checkups and listening to one’s body.

Marcia Cross

Marcia Cross
TMDb

The ‘Desperate Housewives’ actress was diagnosed with anal cancer in 2017. She underwent a rigorous course of radiation and chemotherapy to treat the disease. She has been praised for her willingness to speak openly about a type of cancer that is often considered taboo. Her advocacy has helped raise awareness about the link between the human papillomavirus and certain cancers. She continues to act and use her platform to educate the public.

Vanessa Williams

Vanessa Williams
TMDb

This multi talented actress and singer has managed Type One diabetes for much of her adult life. She has been a vocal supporter of diabetes research and education throughout her career. Despite the demands of Broadway and television she has successfully maintained her health through careful management. She has appeared in successful shows like ‘Ugly Betty’ and ‘Desperate Housewives’. Her long career serves as an example of how to thrive while living with a chronic condition.

Zoe Saldaña

Zoe Saldaña
TMDb

The ‘Avatar’ star was diagnosed with Hashimoto’s thyroiditis which is an autoimmune condition. She follows a strict diet and health regimen to manage the symptoms of the disease. She has spoken about the importance of being proactive regarding health when dealing with hereditary conditions. Her physical roles in films like ‘Guardians of the Galaxy’ require intense training which she manages alongside her condition. She remains one of the most successful actresses in modern cinema.

Daisy Ridley

Daisy Ridley
TMDb

The ‘Star Wars’ lead was diagnosed with endometriosis and polycystic ovary syndrome as a young adult. She recently revealed a diagnosis of Graves’ disease which affects the thyroid and metabolism. She has been open with her fans about the impact these conditions have on her skin and energy levels. Despite these health challenges she has continued to star in major blockbuster films. Her honesty about her health has resonated with many young women facing similar diagnoses.

Lady Gaga

Lady Gaga
TMDb

The ‘A Star Is Born’ actress and singer suffers from fibromyalgia which causes chronic widespread pain. She has had to cancel concert dates and take breaks from acting due to severe physical flare ups. Her documentary ‘Gaga Five Foot Two’ provided a raw look at her struggles with the condition. She continues to advocate for better understanding of invisible illnesses and chronic pain management. Her career remains highly successful across both the music and film industries.

Whoopi Goldberg

Whoopi Goldberg
TMDb

The legendary actress and host of ‘The View’ suffered a life threatening battle with pneumonia and sepsis in 2019. She spent significant time in the hospital and was told she had a very small chance of survival. Her recovery was slow but she eventually returned to her duties on television. She has used her experience to warn others about the dangers of ignoring respiratory symptoms. She continues to be a prominent voice in entertainment and social commentary.

Halle Berry

Halle Berry
TMDb

The Academy Award winner was diagnosed with Type One diabetes early in her career. She has spoken about how the diagnosis forced her to become much more disciplined regarding her nutrition and fitness. Her commitment to health has allowed her to maintain a high level of physical performance in films like ‘John Wick Chapter Three’. She has worked with various organizations to help children manage their diabetes. Her longevity in the industry is a testament to her health management and talent.

Jennifer Grey

Jennifer Grey
TMDb

The ‘Dirty Dancing’ star suffered a severe neck injury in a car accident just before her career took off. Decades later she underwent surgery to address the lingering issues and discovered a cancerous tumor on her thyroid. The surgeon removed the mass and she has since been declared cancer free. She made a triumphant return to the public eye by winning ‘Dancing with the Stars’. Her story is one of overcoming physical trauma and hidden health threats.

Kristin Chenoweth

Kristin Chenoweth
TMDb

The Broadway and television star has lived with Meniere’s disease for many years. This inner ear condition causes severe vertigo and hearing loss which can be devastating for a performer. She has found ways to manage the symptoms while continuing to perform in shows like ‘Wicked’ and ‘Pushing Daisies’. She often speaks about the challenges of working in a loud and bright environment with the condition. Her resilience has allowed her to remain a top talent in the entertainment world.

Elizabeth Taylor

Elizabeth Taylor
TMDb

The iconic actress survived numerous health crises throughout her long life including a brain tumor and congestive heart failure. She also battled severe pneumonia twice and underwent many surgeries for back and hip issues. Despite these constant medical challenges she remained a major film star and a dedicated philanthropist. She used her fame to raise millions of dollars for AIDS research and patient care. Her ability to bounce back from near death experiences earned her a reputation for incredible strength.

Mary Tyler Moore

Mary Tyler Moore
TMDb

The television pioneer was diagnosed with Type One diabetes when she was 33 years old. She became a longtime international chairwoman for the Juvenile Diabetes Research Foundation. Her advocacy helped raise billions of dollars for research into a cure for the disease. She continued to star in ‘The Mary Tyler Moore Show’ and major films while managing her insulin levels. Her legacy includes both her revolutionary work in comedy and her dedication to health causes.

Brooke Shields

Brooke Shields
TMDb

After the birth of her daughter the actress suffered from severe postpartum depression. She wrote a book titled ‘Down Came the Rain’ to share her experience with the debilitating illness. Her openness sparked a national conversation about maternal mental health and the importance of medication. She faced criticism for her stance but stood her ground to help other women. She has continued to have a successful career in television and on Broadway.

Shannen Doherty

Shannen Doherty
TMDb

The ‘Charmed’ actress was first diagnosed with breast cancer in 2015 and underwent extensive treatment. After a period of remission she announced that the cancer had returned as stage four. She has been remarkably transparent about her journey and the realities of living with a terminal diagnosis. Her work has continued in projects like the ‘BH90210’ reboot despite her ongoing health battle. She remains an inspiration for her courage and her commitment to living life to the fullest.

Olivia Newton-John

Olivia Newton-John
TMDb

The ‘Grease’ star was first diagnosed with breast cancer in 1992 and became a leading advocate for health research. She faced the return of the disease multiple times over the next thirty years. She founded a dedicated wellness and research center in Australia to help other cancer patients. Her positive outlook and use of plant based therapies were hallmarks of her journey. She remained a beloved figure in the industry until her passing following her long battle.

Amy Schumer

Amy Schumer
TMDb

The actress and comedian suffered from hyperemesis gravidarum which is a severe form of morning sickness during her pregnancy. She was hospitalized multiple times and had to cancel several tour dates due to the condition. She shared her experience through social media and a documentary series to highlight the severity of the illness. She has also spoken about her diagnosis of Lyme disease and how it affects her energy. She continues to produce and star in successful comedy projects like ‘Life and Beth’.

Delta Burke

Delta Burke
TMDb

The ‘Designing Women’ star has been open about her struggles with clinical depression and Type Two diabetes. She faced intense public scrutiny regarding her weight which complicated her mental health journey. She eventually found the right combination of therapy and medication to manage her conditions. She became a spokesperson for diabetes awareness to help others navigate the complexities of the disease. Her return to acting in guest roles has been welcomed by her longtime fans.

Marcia Wallace

Marcia Wallace
TMDb

The voice of Edna Krabappel on ‘The Simpsons’ was a longtime survivor of breast cancer. She was diagnosed in 1985 and became a prominent activist for early detection and research. She wrote about her health journey in her autobiography and used humor to cope with the challenges. She lived for nearly thirty years after her initial diagnosis while continuing her successful career. Her work on television earned her an Emmy Award and the love of audiences worldwide.

Suzanne Somers

Suzanne Somers
TMDb

The ‘Three’s Company’ star survived breast cancer after being diagnosed in 2000. She became well known for her alternative approach to health and wellness following her recovery. She wrote several books detailing her experiences with traditional and non traditional medical treatments. Despite the controversy surrounding some of her views she remained a successful entrepreneur and actress. She continued to advocate for personal health choices until her passing in 2023.

Kathy Griffin

Kathy Griffin
TMDb

In 2021 the comedian and actress revealed she had been diagnosed with stage one lung cancer despite never having smoked. She underwent surgery to remove half of her left lung as part of her treatment. The recovery process affected her voice which was a significant challenge for her stand up career. She has since returned to the stage and continues to share updates on her health with her followers. Her resilience in the face of both professional and medical hurdles is a key part of her story.

Ann Jillian

Ann Jillian
TMDb

This popular television actress was diagnosed with breast cancer in 1985 at the height of her career. She chose to undergo a double mastectomy and was very public about her decision and recovery. Her story was turned into a successful television movie where she played herself. She became an inspiration for women across the country during a time when cancer was rarely discussed so openly. She has continued to work in the industry and remain active in cancer advocacy.

Valerie Harper

Valerie Harper
TMDb

The star of ‘Rhoda’ survived lung cancer in 2009 but later faced a rare form of brain cancer called leptomeningeal carcinomatosis. Doctors initially gave her only three months to live but she defied the odds for several years. She continued to work and even competed on ‘Dancing with the Stars’ during her treatment. Her bravery and positive attitude in the face of a terminal diagnosis were widely praised. She remained a beloved figure in the television community until her passing.

Christina Ricci

Christina Ricci
TMDb

The ‘Yellowjackets’ star struggled with severe eating disorders and anxiety during her rise to fame as a teenager. She eventually sought treatment and has been vocal about the pressures placed on young women in Hollywood. Her recovery allowed her to maintain a steady and diverse acting career across several decades. She often discusses the importance of mental health support for child actors. Her recent work in ‘Wednesday’ has introduced her to a new generation of fans.

Demi Lovato

Demi Lovato
TMDb

This actress and singer has faced a public battle with bipolar disorder and eating disorders for many years. She survived a life threatening drug overdose in 2018 that resulted in lasting physical health challenges. She has produced documentaries to share the details of her recovery and the importance of sobriety. Her work in ‘Camp Rock’ and ‘Sonny with a Chance’ made her a household name at a young age. She remains a powerful advocate for mental health awareness and addiction recovery.

Jada Pinkett Smith

Jada Pinkett Smith
TMDb

The ‘Gotham’ actress was diagnosed with alopecia areata which causes significant hair loss. She chose to share her diagnosis publicly to help others dealing with the emotional impact of the condition. She has used her talk show to discuss the challenges of living with an autoimmune disorder that affects one’s appearance. Her transparency has sparked wider conversations about beauty standards and health. She continues to work as a performer and producer on various television and film projects.

Gabrielle Union

Gabrielle Union
TMDb

The star of ‘Bring It On’ battled adenomyosis which caused years of physical pain and fertility struggles. She has been very open about her experience with multiple miscarriages and her path to motherhood. Her advocacy has helped bring attention to reproductive health issues that are often misunderstood. She has written books about her life and her journey toward healing and self acceptance. Her career remains vibrant with leading roles in both films and television series.

Amy Brenneman

Amy Brenneman
TMDb

The ‘Judging Amy’ star was diagnosed with ulcerative colitis which eventually required several major surgeries. She underwent a procedure to remove her large intestine after years of managing the chronic illness. She has since become a spokesperson for organizations that support patients with inflammatory bowel disease. Her recovery allowed her to return to demanding roles in shows like ‘The Leftovers’. She continues to advocate for better patient care and medical research.

Tell us which of these courageous women has inspired you most by sharing your thoughts in the comments.

Subscribe
Notify of
guest
0 Comments
Oldest
Newest Most Voted
Inline Feedbacks
View all comments