Here Are the Best TV Shows to Stream this Weekend on Amazon Prime, Including ‘The Runarounds’

Prime Video’s September slate brings a tidy mix of brand-new premieres, international imports, and one full-series library drop—plenty to fill a weekend queue. Below you’ll find short, info-packed rundowns that stick to the essentials: what each show is about, who’s in it, and the key creative names behind it.

Selections are based on this week’s roundups and are prioritized by the most recent releases first, then Prime Video originals, followed by classic or historically significant series. Each entry includes cast, creators, and production details so you can jump straight to the good stuff.

‘The Girlfriend’ (2025)

This six-episode psychological thriller adapts Michelle Frances’ novel about a mother whose suspicions about her adult son’s new partner spiral into a tense battle of wills. The plot tracks dueling perspectives between Laura and Cherry, escalating from uneasy introductions to a high-stakes conflict inside one family.

Robin Wright directs and stars as Laura, with Olivia Cooke as Cherry and Laurie Davidson as Daniel. The ensemble includes Waleed Zuaiter, Anna Chancellor, Francesca Corney, Shalom Brune-Franklin, Leo Suter, and Tanya Moodie. It is produced by Imaginarium Productions with Amazon MGM Studios, with Wright and Michelle Frances among the executive producers.

‘Helluva Boss’ (2020–)

The adult animated series follows I.M.P. (Immediate Murder Professionals), a Hell-based assassination start-up run by Blitzo, with operatives Moxxie and Millie and receptionist Loona. Storylines criss-cross chaos on Earth and politics in Hell, including recurring entanglements with the Goetian demon Stolas.

Created by Vivienne “VivziePop” Medrano, the show is produced by SpindleHorse. Main voice cast features Brandon Rogers, Richard Steven Horvitz, Vivian Nixon, Erica Lindbeck, Bryce Pinkham, and Alex Brightman. The Prime Video rollout includes a refreshed pilot alongside a collected package of the early seasons.

‘Every Minute Counts’ (2024–)

This Spanish-language drama chronicles Mexico City’s 1985 earthquake through parallel threads that unfold in near real time—medical staff at the General Hospital, a reporter navigating the city, and a family trying to reunite. The minute-by-minute structure anchors each episode in frontline rescue work and personal stakes.

Created, written, and directed by Jorge Michel Grau, the series features Jesús Zavala, Osvaldo Benavides, Maya Zapata, Damayanti Quintanar, Everardo Arzate, and Antonio de la Vega. It is produced under the Amazon Studios banner, with the new run extending arcs across hospital, newsroom, and domestic settings.

‘Confidence Queen’ (2025)

Set in the world of high-stakes scams, this Korean series follows Yi-rang and her crew as they target corrupt elites with carefully staged long-cons. Episodes center on mark selection, team roles, and how far the group is willing to go to pull off layered deceptions.

Park Min-young leads the cast alongside Park Hee-soon and Joo Jong-hyuk. The series is directed by Nam Ki-hoon and written by Hong Seung-hyun with Kim Da-hye. It is a Korean remake of ‘The Confidence Man JP’ and streams globally on Prime Video in tandem with local broadcasts.

‘Dish It Out’ (2025)

This unscripted cooking series blends viral food trends with family recipes and surprise, viewer-submitted challenges, hosted by Tilly Ramsay. The format revolves around ingredient reveals, quickfire preparations, and friendly kitchen drop-ins built for bingeable, how-to segments.

Produced by Tastemade Studios in partnership with Amazon MGM Studios, the show features on-camera appearances from Gordon Ramsay and Tana Ramsay alongside a rotating slate of celebrity and creator guests. Production emphasizes fast-turn kitchen setups and repeatable, challenge-driven beats across its episode batches.

‘The Runarounds’ (2025)

A music-driven drama about five recent high-school graduates in Wilmington, North Carolina who form a rock band and chase their first big break. The season follows the group’s songwriting, rehearsals, gigs, and the realities of early adulthood around a fledgling touring life.

Created by Jonas Pate with a teleplay by David Wilcox, the series stars William Lipton, Axel Ellis, Jeremy Yun, Zendé Murdock, and Jesse Golliher, with Brooklyn Decker, Lilah Pate, Mark Wystrach, and Hayes MacArthur in supporting roles. It is produced by Skydance Television with Amazon MGM Studios; the cast performs the show’s original songs.

‘Gen V’ (2023–)

Set within the universe of ‘The Boys’, ‘Gen V’ centers on students at Godolkin University, a Vought-run college training the next generation of corporate-backed superheroes. The story focuses on Marie Moreau and classmates Andre Anderson, Jordan Li, Emma “Little Cricket” Meyer, and Cate Dunlap, whose campus lives collide with a secret research program.

Developed by Craig Rosenberg, Evan Goldberg, and Eric Kripke, the series is produced by Amazon Studios and Sony Pictures Television in association with Kripke Enterprises, Point Grey Pictures, and Original Film. The ensemble includes Jaz Sinclair, Chance Perdomo, London Thor, Derek Luh, Lizze Broadway, and Maddie Phillips, with recurring appearances by Shelley Conn, Clancy Brown, and Sean Patrick Thomas.

‘Top End Bub’ (2025–)

Set after ‘Top End Wedding’, this romantic-comedy series follows Lauren and Ned as they leave Adelaide for Australia’s Northern Territory to raise their orphaned eight-year-old niece. The story mixes family, culture, and community across locations in the Northern Territory and Adelaide.

Created, written, and executive produced by Joshua Tyler and Miranda Tapsell, the show stars Miranda Tapsell and Gwilym Lee, with Ursula Yovich, Huw Higginson, Elaine Crombie, and Tracy Mann returning, and Rob Collins, Brooke Satchwell, Guy Simon, and Clarence Ryan joining the ensemble. Direction is by Christiaan Van Vuuren and Shari Sebbens; production is by Goalpost Pictures.

‘Friday Night Lights’ (2006–2011)

The acclaimed sports drama follows Coach Eric Taylor, his family, and the Dillon Panthers, capturing small-town Texas life through high-school football seasons that double as community rites of passage. The five-season run spans 76 episodes and charts player graduations, leadership changes, and shifting town dynamics.

Developed for television by Peter Berg from H. G. Bissinger’s nonfiction book, the series stars Kyle Chandler, Connie Britton, Aimee Teegarden, Zach Gilford, Taylor Kitsch, Minka Kelly, Jesse Plemons, Michael B. Jordan, and Jurnee Smollett. Jason Katims served as showrunner; production was by Universal Television, Imagine Television, and Film 44 with location shooting around Austin and Pflugerville, Texas.

‘McWalter’ (2025)

This French action-comedy spy project follows legendary elite agent McWalter as he’s framed for orchestrating a string of international attacks, forcing him to go on the run to clear his name. The story tracks his attempts to outmaneuver rival operatives while exposing the conspiracy that targeted him.

Created by Simon Astier, the production features Mister V (Yvick Letexier) in the title role with Géraldine Nakache, William Lebghil, Vincent Dedienne, and François Berléand in supporting parts. The project is mounted by Les Films entre 2 et 4, with writing credits to Astier, Mister V, Vincent Tirel, Freddy Gladieux, and Thibault Valetoux.

Tell us which Prime Video show you’re starting first this weekend—and why—in the comments!