Serena Williams Goes Public With Glp-1 Weight Loss Shot at Super Bowl
Serena Williams remains a master of making headlines, but her most recent splash during the Super Bowl had nothing to do with her backhand. During the Big Game, the 44-year-old tennis icon appeared in a high-profile commercial for the telehealth company Ro, where she candidly discussed her use of GLP-1 medication.
The ad, titled Healthier on Ro, features Williams opening up about her physical transformation and the health milestones she has reached over the last year. The 23-time Grand Slam winner revealed in the commercial that she has lost 34 pounds since beginning her journey with Zepbound, a tirzepatide-based drug.
For Williams, the decision to seek medical help came after years of frustration following the birth of her second daughter, Adira, in 2023. She admitted that no matter what [she] did or how hard [she] trained, the scale simply would not budge, leaving her feeling physically and mentally stuck.
Williams emphasized that the medication was never about taking a “shortcut,” but rather about addressing a metabolic hurdle that willpower alone couldn’t fix. She shared that being on the treatment has made her feel healthier than ever, noting that her cholesterol levels have dropped by 30% and her heart disease risk has plummeted.
She even joked on a recent podcast that her joint pain has vanished so completely that she’s got knees like Megan Thee Stallion now. Her former coach, Patrick Mouratoglou, added a bit of historical context to her struggle, recalling difficult conversations they had about her weight during her competitive years.
He noted that while Williams was often frustrated by his comments, he pushed her because he knew the physical toll of competing at the highest level while carrying extra weight. For Williams, being able to finally reach a weight where she feels light and energized has been a deeply personal victory.
Serena Williams injects herself with a GLP-1 weight loss drug as millions watch the Super Bowl.
— Vigilant Fox 🦊 (@VigilantFox) February 9, 2026
She dances and shows off how “convenient” it is to get GLP-1s using the Ro app.
She even says you can get them in pill form.
I miss the days when the Super Bowl sold beer & trucks.… pic.twitter.com/snXlyGHZfS
As of February 2026, Serena Williams is busier off the court than she ever was on it. She is currently gearing up for the premiere of her new Prime Video docuseries, The CEO Club, which is set to debut on February 23.
The eight-part series, which she also executive-produced, follows Williams and several other trailblazing female leaders as they navigate the high-stakes world of entrepreneurship and global business.
On the production front, Williams is also serving as an executive producer for the highly anticipated Netflix adaptation of Taylor Jenkins Reid’s bestselling novel, Carrie Soto Is Back. The series tells the story of a legendary tennis player who comes out of retirement to defend her record—a plot that has naturally fueled rumors about Williams’ own future in the sport.
While she recently teased fans on The Today Show by saying we’ll see regarding a potential comeback, she currently lists her official occupation as “housewife” on official forms.
Beyond her media ventures, Williams continues to lead her venture capital firm, Serena Ventures, which focuses on funding early-stage companies founded by women and people of color.
Do you think Serena Williams using her platform to normalize medical weight loss will help reduce the stigma for others, or should athletes focus strictly on traditional diet and exercise? Share your thoughts in the comments.